Combination Therapy with Losartan and Pioglitazone Additively Reduces Renal Oxidative and Nitrative Stress Induced by Chronic High Fat, Sucrose, and Sodium Intake
Figure 7
Effects of losartan (L), pioglitazone (P), and their combination (L + P) on expression of Cu/Zn-SOD in kidney. Cu/Zn-SOD mRNA (a) and protein (b) expression was detected by RT-PCR and western blot analysis, respectively. Panels show representative bands and histograms represent optical density values normalized to the corresponding GAPDH or β-actin. Values are expressed as mean ± SD, -5 per group. * versus model group. † versus control group. C: control; M: model.