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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 981561, 9 pages
Review Article

The Role of Metal Regulatory Proteins in Brain Oxidative Stress: A Tutorial

Department of Psychology, University of Nebraska at Kearney, Kearney, NE 68849, USA

Received 14 September 2012; Revised 5 November 2012; Accepted 8 November 2012

Academic Editor: Cinzia Signorini

Copyright © 2012 Wayne Briner. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The proteins that regulate the metabolism of a metal must also play a role in regulating the redox activity of the metal. Metals are intrinsic to a substantial number of biological processes and the proteins that regulate those activities are also considerable in number. The role these proteins play in a wide range of physiological processes involves them directly and indirectly in a variety of disease processes. Similarly, it may be therapeutically advantageous to pharmacologically alter the activity of these metal containing proteins to influence disease processes. This paper will introduce the reader to a number of important proteins in both metal metabolism and oxidative stress, with an emphasis on the brain. Potential pharmacological targets will be considered.