Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

<table>Alteration in mitochondrial membrane potential of control, hesperidin, and rotenone-treated SK-N-SH cells. Rotenone (100 nM) significantly decreased mitochondrial membrane potential, while hesperidin (20 <i>μ</i>g) pretreatment significantly increased MMP in rotenone-treated SK-N-SH cells ((a) and (b)). Values are given as mean ± S.D of four experiments in each group. <svg height="13.95" id="M21" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to control, and <svg height="15.775" id="M22" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to rotenone groups (DMRT).</table>

Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease 

Figure 5 | Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease 