Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

<table>Effect of hesperidin on rotenone-induced Bax and Bcl-2 expressions in SK-N-SH cells. Rotenone (100 nM) significantly enhanced the expression of Bax and diminished the expression of Bcl-2, while hesperidin (20 <i>μ</i>g) pretreatment significantly diminished the expression of Bax and elevated the expression of Bcl-2 in rotenone-treated SK-N-SH cells ((a) and (b)). Western blot data are quantified by using <i>β</i>-actin as an internal control, and the values are expressed as arbitrary units and given as mean ± SD of four experiments in each group. <svg height="13.95" id="M23" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to control, and <svg height="15.775" id="M24" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to rotenone alone treated group.</table>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease 

Figure 6 | Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease 