Figure 1: Effect of 6-OHDA on NADPH oxidase activation in SNpc and striatum. (a) representative Western blots illustrating that 6-OHDA stimulates NADPH-oxidase activation, as evidenced by translocation from the cytosol to the plasma membrane in striatum samples of Wt mice. (b) representative confocal microscopy images illustrating immunostaining in striatum and SNpc of Wt mice. In (c) and (d), the graphs depict the mean optical density data of 5 samples in each case. * (Wt saline versus Wt 6-OHDA).