NADPH Oxidase and the Degeneration of Dopaminergic Neurons in Parkinsonian Mice

Figure 2

Expression of p47^phox in striatum of Wt mice after 6-OHDA injection. (a) representative p47^phox immunostaining in neurons and microglia in striatum. Immunostaining was carried out using antibodies for p47^phox (shown in green) together with NeuN (top), OX42 (middle), and GFAP (bottom). Microglia, astrocytes, and neuronal markers are shown in red. In striatum, p47^phox is expressed in neurons, microglial cells, and rarely with astrocytes. In (b), (c), and (d) the graphs represent the percentage of neurons, microglial cells and astrocytic cells expressing p47^phox, respectively. **𝑃<0.01 (Wt saline versus Wt 6-OHDA).