NADPH Oxidase and the Degeneration of Dopaminergic Neurons in Parkinsonian Mice

Figure 6

Effects of 6-OHDA on TH immunoreactivity in the SNpc. (a) representative digital images of TH immunoreactivity in mice of the groups: the saline-injected Wt, 6-OHDA-injected Wt, saline-injected gp91^phox−/−, 6-OHDA-injected gp91^phox−/−, apocynin-treated Wt injected with saline, and apocynin-treated Wt injected with 6-OHDA. (b) the graph depicts the mean optical density data of 5 to 7 samples in each case. ***𝑃<0.001 (Wt saline versus Wt 6-OHDA), **𝑃<0.01 (Wt apocynin saline versus Wt apocynin 6-OHDA), and *𝑃<0.05 Wt apocynin 6-OHDA versusgp91^phox−/− 6-OHDA).

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