Review Article
The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance
Table 3
The role of Nrf2 in insulin resistance.
| Insulin resistance and Nrf2 | Regulation of Nrf2 | Suggested mechanism | Reference |
| Nrf2insulin resistance | Keap1-KD, Lep(ob/ob)-Keap1-KD mice | Regulation of genes involved in glucose uptake and tolerance | [20] | Nrf2insulin resistance | Nrf2-KO mice | FGF21 | [34] | Nrf2insulin resistance | Nrf2-null mice, Keap1-KD mice | Hepatic expression of insulin like growth factor binding protein-1 (Igfbp-1) and FGF21 | [35] | Nrf2insulin resistance | Global Nrf2-KO mice Myeloid-selective Nrf2 deficiency mice | Inflammatory gene expression | [41] | Nrf2insulin resistance | STZ-treated Nrf2-null mice | Gluconeogenesis and Glycolysis-related genes | [42] | Nrf2insulin resistance | Chronic iAs exposure | Inflammatory gene and GLUT4 expression | [44] | Nrf2insulin resistance | Nrf2 agonist: oltipraz | AMPK signalling, p70S6 kinase, and GLUT4 expression | [27] | Nrf2insulin resistance | Nrf2 agonist: ellagic acid | Attenuation of oxidative stress and inflammation in liver | [28] | Nrf2insulin resistance | Nrf2 agonist: curcumin | Muscular mitochondrial redox balance | [30] | Nrf2insulin resistance | Nrf2 agonist: curcumin | Adipose, hepatic, and systemic inflammation | [31] | Nrf2insulin resistance | Nrf2 agonist: resveratrol | Hepatic oxidative stress | [33] | Nrf2insulin resistance | Nrf2 agonist: resveratrol | Extracellular signal regulated kinase (ERK) pathway | [47] | Nrf2insulin resistance | Nrf2 agonist (Dh404) | ERK pathway | [48] |
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