Table 1: Determination of the lipid peroxidation levels in hippocampus, striatum, frontal cortex, and cerebellum of mice treated with 5TIO1 at doses 0.1, 1, and 10 mg kg−1.

GroupsTBARS (mmol min−1 µg protein−1)
HippocampusStriatumFrontal cortexCerebellum

Vehicle1.36 ± 0.141.34 ± 0.061.54 ± 0.041.43 ± 0.06
5TIO1 0.10.13 ± 0.03a0.13 ± 0.01a0.12 ± 0.02a0.13 ± 0.03a
5TIO1 10.16 ± 0.01a0.16 ± 0.01a0.15 ± 0.01a0.18 ± 0.03a,b
5TIO1 100.15 ± 0.01a0.15 ± 0.02a0.15 ± 0.01a0.17 ± 0.03a,b

Male mice (25–30 g, 2 month-old) were intraperitoneally treated with doses of 5TIO1 (0.1, 1, and 10 mg kg−1, , 5TIO1 groups) and the control animals with 0.05% Tween 80 dissolved in 0.9% saline ( , Vehicle). Results are expressed as means ± SD for the number of animals shown inside in parenthesis. Differences in experimental groups were determined by two-tailed Analysis of Variance (ANOVA). compared to the control group (ANOVA and -Student-Neuman-Keuls as post hoc test); compared to the 5TIO1 0.1 group (ANOVA and -Student-Neuman-Keuls as post hoc test).