Oxidative Medicine and Cellular Longevity / 2013 / Article / Tab 2

Research Article

Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?

Table 2

Nitrite content in hippocampus, striatum, frontal cortex, and cerebellum of mice treated with 5TIO1 at doses 0.1, 1, and 10 mg kg−1.

GroupsNitrite (µM)
HippocampusStriatumFrontal cortexCerebellum

Vehicle95.86 ± 7.6794.71 ± 3.3576.57 ± 1.7282.43 ± 1.99
5TIO1 0.15.11 ± 1.16a6.00 ± 1.82a6.49 ± 1.97a6.93 ± 2.25a
5TIO1 16.36 ± 2.73a4.98 ± 1.51a6.19 ± 3.24a4.81 ± 1.43a
5TIO1 107.14 ± 2.62a9.04 ± 6.54a8.50 ± 3.33a9.04 ± 4.76a

Male mice (25–30 g, 2 month-old) were intraperitoneally treated with doses of 5TIO1 (0.1, 1, and 10 mg kg−1, , 5TIO1 groups) and the control animals with 0.05% Tween 80 dissolved in 0.9% saline ( 7, Vehicle). Results are expressed as means ± SD for the number of animals shown inside in parenthesis. Differences in experimental groups were determined by two-tailed Analysis of Variance (ANOVA). compared to the control group (ANOVA and -Student-Neuman-Keuls as post hoc test).