Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?

Table 4

Superoxide dismutase activity in hippocampus, striatum, frontal cortex, and cerebellum of mice treated with 5TIO1 at doses 0.1, 1, and 10 mg kg⁻¹.

Groups	Superoxide dismutase (U µg of protein^−1)
	Hippocampus	Striatum	Frontal cortex	Cerebellum
Vehicle	2.24 ± 0.41	2.64 ± 0.49	2.20 ± 0.07	3.23 ± 0.35
5TIO1 0.1	3.56 ± 1.63^a	2.86 ± 0.31^a	2.52 ± 0.23^a	3.95 ± 1.84^a
5TIO1 1	3.14 ± 0.42^a	2.54 ± 0.89	2.39 ± 0.44^a	2.81 ± 1.96
5TIO1 10	2.16 ± 0.79	2.42 ± 0.38	2.17 ± 0.34	2.70 ± 1.34

Male mice (25–30 g, 2 month-old) were intraperitoneally treated with doses of 5TIO1 (0.1, 1, and 10 mg kg⁻¹, 𝑛=7, 5TIO1 groups) and the control animals with 0.05% Tween 80 dissolved in 0.9% saline (𝑛=7, Vehicle). Results are expressed as means ± SD for the number of animals shown inside in parenthesis. Differences in experimental groups were determined by two-tailed Analysis of Variance (ANOVA). ^a𝑃<0.05 compared to the control group (ANOVA and 𝑡-Student-Neuman-Keuls as post hoc test).