Oxidative Medicine and Cellular Longevity / 2013 / Article / Tab 4

Research Article

Is Oxidative Stress in Mice Brain Regions Diminished by 2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile?

Table 4

Superoxide dismutase activity in hippocampus, striatum, frontal cortex, and cerebellum of mice treated with 5TIO1 at doses 0.1, 1, and 10 mg kg−1.

GroupsSuperoxide dismutase (U µg of protein−1)
HippocampusStriatumFrontal cortexCerebellum

Vehicle2.24 ± 0.412.64 ± 0.492.20 ± 0.073.23 ± 0.35
5TIO1 0.13.56 ± 1.63a2.86 ± 0.31a2.52 ± 0.23a3.95 ± 1.84a
5TIO1 13.14 ± 0.42a2.54 ± 0.892.39 ± 0.44a2.81 ± 1.96
5TIO1 102.16 ± 0.792.42 ± 0.382.17 ± 0.342.70 ± 1.34

Male mice (25–30 g, 2 month-old) were intraperitoneally treated with doses of 5TIO1 (0.1, 1, and 10 mg kg−1, , 5TIO1 groups) and the control animals with 0.05% Tween 80 dissolved in 0.9% saline ( , Vehicle). Results are expressed as means ± SD for the number of animals shown inside in parenthesis. Differences in experimental groups were determined by two-tailed Analysis of Variance (ANOVA). compared to the control group (ANOVA and -Student-Neuman-Keuls as post hoc test).