Table 1: Effects of hyper- or hypothyroidism on the activity/abundance of antioxidant enzymes and the oxidative status of various tissues.

HyperthyroidismHypothyroidism
TissueSODGPxCATGSHLpxChlCrbSpeciesSODGPxCATGSHLpxChlCrbSpecies

HeartRat [18]Rat [18]
Rat [48]Rat [41]
Rat [39]Rat [39]
Rat [49]Rat [49]
Rat [50]Rat young [42]
Rat young [42]Rat old [42]
Rat old [42]

LiverMouse [51]Mouse [51]
Rat [18]Rat [18]
Rat [40]Rat [52]
↑↑Rat [52]Rat [53]
Rat [53]Rat [39]
Rat [54]Rat [49]
Rat [39]
Rat [49]
Rat [55]
Rat [50]
Rat [56]
Rat [57]
Rat [58]
Microsomes Rat [32]
Mitochondria Rat [54]

Skeletal muscleMouse [35]Duck [59]
Rat [39]Mouse [35]
Rat [39]
Oxidative Rat [18]Rat [18]
Glycolytic Rat [18]

Blood
Plasma Rat [60]Rat [61]
Rat [50]Human [62]
Rat [63]Human [64]
Human [65]Human [66]
Human [67]Human [68]
Human [69]Human [70]
Human [71]↑↑Human [72]
Human [73]Human [74]
Human [75]Human [76]
Human [66]Human [77]
Human [78]Human [78]
Erythrocytes Rat [79]Rat [79]
Rat [80]
Rat [18]
Cat [81]
Human [73]

Brain
Homogenate Rat [49]Rat [49]
↑↑Rat juvenile [27]Rat neonate [82]
Rat neonate [83]Rat neonate [83]
Mitochondria ↑↑Rat [19]Rat [19]
Cortex ↑↑Rat [19]Rat [19]
Rat [84]Rat [85]
Rat old [86]Rat neonate [87]
Rat old [86]
Hippocampus Rat [61]
Rat [88]
Rat neonate [89]
Cerebellum Rat [84]Rat [85]
Rat [88]
Rat neonate [83]Rat juvenile [90]
Rat neonate [90]
Rat neonate [83]
Medulla Rat neonate [83]Rat neonate [83]

Antioxidant enzymes and substrates: SOD: superoxide dismutase (no distinction is made between Cu/Zn-SOD and Mn-SOD); GPx: glutathione peroxidase; CAT: catalase; GSH: reduced glutathione.
Oxidative status: Lpx: lipid peroxidation (measured as thiobarbituric acid-reactive substances: TBARS or malondialdehyde production); Chl: chemiluminescence; Crb: carbonylated proteins.
: decrease; ↑: increase; —: no change. Double arrows represent a highly significant effect ( ).