Obstructive Sleep Apnea, Oxidative Stress and Cardiovascular Disease: Lessons from Animal Studies

Figure 1

Schematic representation of the mouse/rat model simulating OSA-associated CIH. Animals are housed in plexiglass chambers and are repetitively exposed either to room air (i.e., 21%  O₂) or nitrogen (i.e., hypoxia). Exposure to CIH may be synchronized to the sleep-wake cycle by simultaneously measuring EEG and EMG activities of animals.