Figure 3: L-NAME reverses the cardioprotective effects of sivelestat in ischemia-reperfusion. (a) Infarct size and (b) recovery of rate pressure product. During low flow, hearts were treated with L-NAME, sivelestat, or both. Though sivelestat preserves RPP and reduces infarct following IR, coinfusion of L-NAME and sivelestat offered no preservation of RPP or infarct reduction as compared to hearts that received vehicle during low flow ( /group). n.s.: nonsignificant.