Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2

Table 2

Protein domains of NF-E2-related factor 2.

Domains	Amino acid positions*		Predicted functions
	Human (605 aa)	Mouse (597 aa)
Neh2	16–89; DLG motif 17–32,; ETGF motif 77–82	16–89	KEAP1 repression through DLG/ETGF motif-DC motif binding, fast, redox-sensitive proteasomal degradation.
Neh4	111–134	111–134	Translocation and transactivation. Phosphorylation or CBP binding.
Neh5	182–209	172–201
Neh6	337–394; (or 338–388)	328–385	Degron motif-associated constitutive turnover, slow, redox-insensitive (Keap1-independent).
Neh1	435–568; basic motif 503–518; leucine zipper 525–539	427–560; basic motif 494–509; leucine zipper 517–531	Dimerization for nuclear translocation, DNA binding through basic motif-leucine zipper.
Neh3	569–605	561–597	CHD6 binding, stability, or transactivation.

∗Varies slightly among publications.