Table 2: Protein domains of NF-E2-related factor 2.

DomainsAmino acid positions*Predicted functions
Human (605 aa)Mouse (597 aa)

Neh216–89  
DLG motif 17–32,
ETGF motif 77–82
16–89KEAP1 repression through DLG/ETGF motif-DC motif binding, fast, redox-sensitive proteasomal degradation.
Neh4111–134111–134Translocation and transactivation. Phosphorylation or CBP binding.
Neh5182–209172–201
Neh6337–394
(or 338–388)
328–385Degron motif-associated constitutive turnover, slow, redox-insensitive (Keap1-independent).
Neh1435–568
basic motif 503–518  
leucine zipper 525–539
427–560
basic motif 494–509
leucine zipper 517–531
Dimerization for nuclear translocation, DNA binding through basic motif-leucine zipper.
Neh3569–605561–597CHD6 binding, stability, or transactivation.

Varies slightly among publications.