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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 296898, 5 pages
Research Article

Naltrexone Reverses Ethanol-Induced Rat Hippocampal and Serum Oxidative Damage

1Departamento de Ciencias Biomédicas, Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Moncada, 46113 Valencia, Spain
2Facultad de Medicina, Universidad Católica de Valencia “San Vicente Mártir”, C/ Quevedo 2, 46001 Valencia, Spain
3Facultad de Ciencias de la Salud, Universitat Jaume I, 12071 Castellón, Spain

Received 7 August 2013; Revised 17 October 2013; Accepted 11 November 2013

Academic Editor: Madia Trujillo

Copyright © 2013 Inmaculada Almansa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Naltrexone, an antagonist of μ-opioid receptors, is clinically used as adjuvant therapy of alcohol dishabituation. The aim of the present work was to test the effect of 1 mg/kg body weight of naltrexone to revert oxidative stress-related biochemical alterations, in the hippocampus and serum of chronic alcoholic adult rats. Malondialdehyde concentration was increased and glutathione peroxidase activity was decreased in hippocampus and serum of alcohol-treated rats. Naltrexone treatment restored these alterations. The in vitro antioxidant ability of Ntx could not justify these effects considering the doses used. Thus this apparent protective effect of Ntx can only be attributed to its pharmacological effects, as herein discussed.