Comparative Effects of Biodynes, Tocotrienol-Rich Fraction, and Tocopherol in Enhancing Collagen Synthesis and Inhibiting Collagen Degradation in Stress-Induced Premature Senescence Model of Human Diploid Fibroblasts

<table>Effects of biodynes, TRF, and tocopherol on <i>MMP2 </i>gene expression and MMP-2 activity in HDFs. <i>MMP2 </i>expression (a). TRF, tocopherol and BTT downregulated <i>MMP2 </i>compared to SIPS. MMP-2 activity (b). Biodynes, TRF, tocopherol, and BTT significantly decreased, the MMP-2 activity compared to SIPS. <sup>a</sup>Denotes <svg height="11.375" id="M21" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to SIPS. Data are presented as the mean of three experiments ±S.D, <svg height="11.225" id="M22" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>.</table>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Comparative Effects of Biodynes, Tocotrienol-Rich Fraction, and Tocopherol in Enhancing Collagen Synthesis and Inhibiting Collagen Degradation in Stress-Induced Premature Senescence Model of Human Diploid Fibroblasts 

Figure 4 | Comparative Effects of Biodynes, Tocotrienol-Rich Fraction, and Tocopherol in Enhancing Collagen Synthesis and Inhibiting Collagen Degradation in Stress-Induced Premature Senescence Model of Human Diploid Fibroblasts 