Comparative Effects of Biodynes, Tocotrienol-Rich Fraction, and Tocopherol in Enhancing Collagen Synthesis and Inhibiting Collagen Degradation in Stress-Induced Premature Senescence Model of Human Diploid Fibroblasts

<table>Effects of biodynes, TRF, and tocopherol on <i>MMP3 </i>gene expression and MMP-3 activity in HDFs. <i>MMP3 </i>expression (a). Biodynes, TRF, tocopherol, and BTT significantly downregulated <i>MMP3 </i>compared to SIPS. MMP-3 activity (b). Biodynes, TRF, tocopherol, and BTT significantly decreased MMP-3 activity. <sup>a</sup>Denotes <svg height="11.375" id="M25" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to SIPS. Data are presented as the mean of three experiments ±S.D, <svg height="11.225" id="M26" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>.</table>

Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Comparative Effects of Biodynes, Tocotrienol-Rich Fraction, and Tocopherol in Enhancing Collagen Synthesis and Inhibiting Collagen Degradation in Stress-Induced Premature Senescence Model of Human Diploid Fibroblasts 

Figure 5 | Comparative Effects of Biodynes, Tocotrienol-Rich Fraction, and Tocopherol in Enhancing Collagen Synthesis and Inhibiting Collagen Degradation in Stress-Induced Premature Senescence Model of Human Diploid Fibroblasts 