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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 298574, 8 pages
http://dx.doi.org/10.1155/2013/298574
Research Article

Comparative Effects of Biodynes, Tocotrienol-Rich Fraction, and Tocopherol in Enhancing Collagen Synthesis and Inhibiting Collagen Degradation in Stress-Induced Premature Senescence Model of Human Diploid Fibroblasts

1Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
2R&D Plantation and Agri-Business Division, Sime Darby Research Sdn Bhd, 42960 Carey Island, Selangor, Malaysia

Received 16 July 2013; Accepted 1 November 2013

Academic Editor: Okezie I. Aruoma

Copyright © 2013 Suzana Makpol et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Varani, “Fibroblast aging: intrinsic and extrinsic factors,” Drug Discovery Today: Therapeutic Strategies, vol. 7, no. 3-4, pp. 65–70, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Jenkins, “Molecular mechanisms of skin ageing,” Mechanisms of Ageing and Development, vol. 123, no. 7, pp. 801–810, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. G. J. Fisher, S. Kang, J. Varani et al., “Mechanisms of photoaging and chronological skin aging,” Archives of Dermatology, vol. 138, no. 11, pp. 1462–1470, 2002. View at Google Scholar · View at Scopus
  4. J. Varani, M. K. Dame, L. Rittie et al., “Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation,” The American Journal of Pathology, vol. 168, no. 6, pp. 1861–1868, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Péterszegi, E. Andrès, J. Molinari, V. Ravelojaona, and L. Robert, “Effect of cellular aging on collagen biosynthesis. I. Methodological considerations and pharmacological applications,” Archives of Gerontology and Geriatrics, vol. 47, no. 3, pp. 356–367, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Varani, R. L. Warner, M. Gharaee-Kermani et al., “Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin,” Journal of Investigative Dermatology, vol. 114, no. 3, pp. 480–486, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. B. H. Chen, Y. Wen, H. Li, and M. L. Polan, “Collagen metabolism and turnover in women with stress urinary incontience and pelvic prolapse,” International Urogynecology Journal and Pelvic Floor Dysfunction, vol. 13, no. 2, pp. 80–87, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. G. J. Fisher, T. Quan, T. Purohit et al., “Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin,” The American Journal of Pathology, vol. 174, no. 1, pp. 101–114, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Oishi, Z. W. Fu, Y. Ohnuki, H. Kato, and T. Noguchi, “Molecular basis of the alteration in skin collagen metabolism in response to in vivo dexamethasone treatment: effects on the synthesis of collagen type I and III, collagenase, and tissue inhibitors of metalloproteinases,” The British Journal of Dermatology, vol. 147, no. 5, pp. 859–868, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. P. M. Crofton, J. C. Wade, M. R. H. Taylor, and C. V. Holland, “Serum concentrations of carboxyl-terminal propeptide of type I procollagen, amino-terminal propeptide of type III procollagen, cross-linked carboxyl-terminal telopeptide of type I collagen, and their interrelationships in schoolchildren,” Clinical Chemistry, vol. 43, no. 9, pp. 1577–1581, 1997. View at Google Scholar · View at Scopus
  11. L. Rittié and G. J. Fisher, “UV-light-induced signal cascades and skin aging,” Ageing Research Reviews, vol. 1, no. 4, pp. 705–720, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. G. J. Fisher, S. Datta, Z. Wang et al., “c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid,” Journal of Clinical Investigation, vol. 106, no. 5, pp. 663–670, 2000. View at Google Scholar · View at Scopus
  13. S. E. G. Fligiel, J. Varani, S. C. Datta, S. Kang, G. J. Fisher, and J. J. Voorhees, “Collagen degradation in aged/photodamaged skin in vivo and after exposure to matrix metalloproteinase-1 in vitro,” Journal of Investigative Dermatology, vol. 120, no. 5, pp. 842–848, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Harman, “Aging: a theory based on free radical and radiation chemistry,” Journal of Gerontology, vol. 11, no. 3, pp. 298–300, 1956. View at Google Scholar · View at Scopus
  15. Q. M. Chen, K. R. Prowse, V. C. Tu, S. Purdom, and M. H. K. Linskens, “Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts,” Experimental Cell Research, vol. 265, no. 2, pp. 294–303, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Chainiaux, J. P. Magalhaes, F. Eliaers, J. Remacle, and O. Toussaint, “UVB-induced premature senescence of human diploid skin fibroblasts,” International Journal of Biochemistry and Cell Biology, vol. 34, no. 11, pp. 1331–1339, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. Q. Chen and B. N. Ames, “Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 10, pp. 4130–4134, 1994. View at Google Scholar · View at Scopus
  18. M. Bentinger, K. Brismar, and G. Dallner, “The antioxidant role of coenzyme Q,” Mitochondrion, vol. 7, pp. S41–S50, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. V. V. Padyachi and J. V. Gruber, “Biodynes TRF for personal care and cosmetics,” Speciality Chemicals, vol. 24, no. 1, pp. 19–19, 2004. View at Google Scholar
  20. A. Zainuddin, K. H. Chua, N. A. Rahim, and S. Makpol, “Effect of experimental treatment on GAPDH mRNA expression as a housekeeping gene in human diploid fibroblasts,” BMC Molecular Biology, vol. 11, article 59, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. V. Bassaneze, A. A. Miyakawa, and J. E. Krieger, “A quantitative chemiluminescent method for studying replicative and stress-induced premature senescence in cell cultures,” Analytical Biochemistry, vol. 372, no. 2, pp. 198–203, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Wang, L. A. Garza, S. Kang et al., “In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin,” Archives of Dermatology, vol. 143, no. 2, pp. 155–163, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Varani, D. Spearman, P. Perone et al., “Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro,” The American Journal of Pathology, vol. 158, no. 3, pp. 931–942, 2001. View at Google Scholar · View at Scopus
  24. M. Mawal-Dewan, A. Lorenzini, L. Frisoni, H. Zhang, V. J. Cristofalo, and C. Sell, “Regulation of collagenase expression during replicative senescence in human fibroblasts by Akt-forkhead signaling,” The Journal of Biological Chemistry, vol. 277, no. 10, pp. 7857–7864, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Steinbrenner, M. C. Ramos, D. Stuhlmann, H. Sies, and P. Brenneisen, “UVA-mediated downregulation of MMP-2 and MMP-9 in human epidermal keratinocytes,” Biochemical and Biophysical Research Communications, vol. 308, no. 3, pp. 486–491, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Takada, R. Suzuki, M. Guentert, S. Inomata, C. Hamada, and T. Sakiguchi, “Anti-aging composition and collagen production promoting composition,” US Patent Application 12/320, 088, 2009.
  27. H. H. Ahmed, “Modulatory effects of vitamin E, acetyl-l-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model,” Experimental and Toxicologic Pathology, vol. 64, no. 6, pp. 549–556, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. K. Nakamura and S. T. Omaye, “Vitamin E-modulated gene expression associated with ROS generation,” Journal of Functional Foods, vol. 1, no. 3, pp. 241–252, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Zingg, “Modulation of signal transduction by vitamin E,” Molecular Aspects of Medicine, vol. 28, no. 5-6, pp. 481–506, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Magalhães, R. Ferreira, M. J. Neuparth, P. J. Oliveira, F. Marques, and A. Ascensão, “Vitamin E prevents hypobaric hypoxia-induced mitochondrial dysfunction in skeletal muscle,” Clinical Science, vol. 113, no. 11-12, pp. 459–466, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. Q. Jiang, S. Christen, M. K. Shigenaga, and B. N. Ames, “γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention,” The American Journal of Clinical Nutrition, vol. 74, no. 6, pp. 714–722, 2001. View at Google Scholar · View at Scopus
  32. C. K. Sen, S. Khanna, and S. Roy, “Tocotrienols: vitamin E beyond tocopherols,” Life Sciences, vol. 78, no. 18, pp. 2088–2098, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. K. S. Lee, K. Y. Oh, and B. C. Kim, “Effects of dehydroepiandrosterone on collagen and collagenase gene expression by skin fibroblasts in culture,” Journal of Dermatological Science, vol. 23, no. 2, pp. 103–110, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. C. K. Sen, S. Khanna, and S. Roy, “Tocotrienol: the natural vitamin E to defend the nervous system?” Annals of the New York Academy of Sciences, vol. 1031, pp. 127–142, 2004. View at Publisher · View at Google Scholar · View at Scopus