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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 303181, 9 pages
Research Article

Age-Dependent Accumulation of 8-Oxoguanine in the DNA and RNA in Various Rat Tissues

1Graduate School, Wenzhou Medical College, University Town, Wenzhou, Zhejiang 325035, China
2The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, No. 1 Dahua Road, Dongdan, Beijing 100730, China
3Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 9 Santiao, Dongdan, Dongcheng District, Beijing 100730, China
4Department of Pharmacology, Wenzhou Medical College, University Town, Wenzhou, Zhejiang 325035, China
5Frontier Research Center, Fukuoka Dental College, Fukuoka 814-0193, Japan

Received 4 February 2013; Accepted 20 March 2013

Academic Editor: Gabriele Saretzki

Copyright © 2013 Ben Nie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplementary Material provide the detailed information about the experimental procedure, including "elution conditions for each sample", "Mass conditons for each compound", and "HPLC chromatograms of creatinine".

  1. Supplementary Material