Research Article
NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants
Figure 1
Histological analysis of livers from Nrf2-null, wild-type, and Keap1-HKO mice treated with (25 μL/kg, ip, 16 h), acetaminophen (APAP, 400 mg/kg, ip for 8 h), microcystin (50 μg/kg, ip, 8 h), phalloidin (1.5 mg/kg, ip, 8 h), furosemide (250 mg/kg, ip 24 h), and D-galactosamine/endotoxin (400 mg/10 μg/kg, ip, 8 h). Arrows indicate hemorrhage and inflammation and arrowheads indicate hepatocellular necrosis (200x).
