NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants

Table 2

The “graded Nrf2 activation” model in protecting against hepatotoxicants.

Hepatotoxicants	Dose, route, and time	Nrf2-null	Wild-type	Keap1-Kd	Keap1-HKO	References
Carbon tetrachloride	25 μl/kg, ip, 16 h	4610 ± 920	2970 ± 690	2110 ± 464	503 ± 301*	Unpublished
Acetaminophen	500 mg/kg, ip, 8 h	1010 ± 385	615 ± 165	266 ± 93*	198 ± 43*	Unpublished
Microcystin	50 μg/kg, ip, 8 h	1010 ± 385	615 ± 165	266 ± 93*	198 ± 43*	Unpublished
Phalloidin	1.5 mg/kg, ip, 8 h	4130 ± 705	3630 ± 1185	1410 ± 348	210 ± 87*	Unpublished
Furosemide	250 mg/kg, ip, 18 h	1095 ± 365	570 ± 393	40 ± 8*	35 ± 5*	Unpublished
Cadmium	3.5 mg/kg, ip, 8 h	995 ± 152	675 ± 98	201 ± 21*	111 ± 15*	Wu et al., 2012a
Arsenic	100 umol/kg, ip, 8 h	165 ± 52	120 ± 53	66 ± 29	52 ± 18*	Unpublished
Ethanol	5 g/kg, po, 6 h	70 ± 20	88 ± 25	46 ± 11	38 ± 5*	Wu et al., 2012b
Diquat	125 mg/kg, ip, 6 h	604 ± 65	412 ± 48	302 ± 16*	N.D.	Wu et al., 2012c
Bromobenzene	0.7 ml/kg, ip, 24 h	1650 ± 235	1550 ± 211	N.D.	175 ± 35*	Unpublished
Allyl Alcohol	85 mg/kg, ip, 24 h	1130 ± 211	1050 ± 330	N.D.	220 ± 65*	Unpublished
Lithocholic acid	0.4% in diet, 7 d	1390 ± 216	985 ± 211	450 ± 112	105 ± 25*	Unpublished
D-Gal/LPS	400 mg/10 ug/kg, ip, 6 h	4630 ± 1250	3730 ± 660	5430 ± 1005	3650 ± 535	Unpublished
Fas Jo2 antibody	5 μg/mouse, ip, 8 h	4815 ± 1310	5530 ± 2105	5545 ± 1950	6170 ± 2510	Unpublished

Data represent mean ± SEM of serum ALT values (𝑛=6–10), *significantly different from wild-type mice, 𝑃<0.05. N.D.: not detected.