NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants

Table 4

Expression of DNA damage genes and genes of cell death.

	Nrf2-null	Wild-type	Keap1-Kd	Keap1-HKO
DNA damage
Gadd45	++++	+++	++	+
Gadd153	++++	+++	++	+
Apoptosis
Noxa	+++	++	+	+
Bax	++	++	+	+
Bad	++	++	+	+
Casp3	++	++	+	+

Gadd45: the growth arrest and DNA damage-inducible 45 proteins; Gadd153/Chop10: C/EBP homologous protein 10; Noxa: a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis; Bax: Bcl-2 associated protein X; Bad: BCL2-associated agonist of cell death; Casp3: caspases 3. “+++” indicates significant increase; “++” indicates moderate increase; “+” indicates slight mild increase. These inflammatory gene expression profiles are similar for the hepatotoxicity produced by acetaminophen, carbon tetrachloride, microcystin, phalloidin, and furosemide.