Influence of Block of NF-Kappa B Signaling Pathway on Oxidative Stress in the Liver Homogenates

Table 1

Effect of administration of BAY 11-7082 on oxidative stress parameters in liver homogenates of rats with endothelin-1-induced endotoxemia. Mean ± S.E.M. (𝑛=8).

Parameter	0.9% NaCl	ET-1; (1.25 mg/kg b.w.)	ET-1; (12.5 mg/kg b.w.)	BAY 11-7082; (10 mg/kg b.w.); + ET 1; (12.5 mg/kg b.w.)
TBARS (𝜇M)	5.96 ± 1.075	10.93 ± 1.16^###	22.26 ± 2.43^*#∧ ∧	0.44 ± 0.22***
H2O2 (𝜇M)	1.44 ± 0.15	1.79 ± 0.06****	2.56 ± 0.15^*∧##	1.55 ± 0.19
GSH/GSSG ratio	7.13 ± 1.09	3.69 ± 0.27^*#	3.84 ± 1.02^####	7.30 ± 0.46

TBARS: thiobarbituric acid-reactive substances; H₂O₂: hydrogen peroxide; redox status: GSH/GSSG ratio; ^∗𝑃<0.001,**𝑃<0.01, ***𝑃<0.02, and ****𝑃<0.05 versus saline; ^#𝑃<0.001, ^##𝑃<0.01, ^###𝑃<0.02, and ^####𝑃<0.05 versus BAY 11-7082 + ET-1; ^∧𝑃<0.001, ^{∧ ∧}𝑃<0.01 versus ET-1 (1.25 mg/kg b.w.).