Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress
Enhanced lipid droplet (LD) formation upon hyperoxia in mouse. C57BL/6 mice were exposed to room air (a) or hyperoxia (95% O2, 5% N2) (b) for 72 h. Transmission electron microscopy (TEM) images of the lung tissue were captured. The formation of LDs (white arrowhead) in alveolar type II (ATII) cells increased upon hyperoxic exposure in the mouse lung. A select image in (b) (inset) was photographed at high power (c). *One of the LDs was invaginated by growing lysosomes as reported previously . Bar = 500 nm. Approximately 50 images were captured from at least 3 individual mice of each group.