Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress
Myocardial ischemia induces LD formation. The AMI rat model was established by ligation of the left anterior descending coronary artery. The hearts were, then, harvested at 40 minutes, 24 hours after ligation in the AMI group. The rats in the sham-operated group underwent the same procedure except for the ligation of the coronary artery (a). The hearts were examined by TEM. The formation of LDs was not observed in the heart from 40-minute ligation (subinfarct, (b)) while remarked at 24-hour ligation (white arrowhead, (c) and (d)).