Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress
LD formation in a sepsis model in mice. Cecal ligation and puncture (CLP, 19-gauge, 1-hole) was carried out to induce polymicrobial sepsis in mice. CLP greatly enhances the formation of LDs (arrowhead) in the liver (b) compared with those in sham-operated control mice (a). To a lesser extent, the kidneys exhibited an increased number of LDs in the epithelial cells (d) compared with the control (c). Bar represents 500 nm. Approximately 50 images were captured from at least 3 individual mice of each group.