Oxidative Medicine and Cellular Longevity / 2013 / Article / Fig 2

Review Article

Redox Regulation in Amyotrophic Lateral Sclerosis

Figure 2

Redox dysfunction and its relationship to other pathologies in ALS. Alteration in the enzymatic activity of PDI due to redox dysregulation and oxidative stress can further increase the load of misfolded proteins, ER stress, oxidative stress, autophagy, mitochondrial dysfunction, and axonal impairment leading to neuronal cell death.