Resveratrol Protects the Brain of Obese Mice from Oxidative Damage

Table 2

Effect of resveratrol on the levels of enzymic antioxidants in lean and obese mice brains.

Parameter	Lean	Lean + Res	ob/ob	ob/ob + Res
SOD1	71.80 ± 3.82	72.62 ± 3.53	46.96±3.56^a∗∗∗	63.75±3.26^b∗∗∗
SOD2	80.11 ± 4.93	80.61 ± 5.14	71.41±4.43^a∗∗	77.15±4.74^bNS
Catalase	6.93 ± 0.49	6.95 ± 0.61	4.07±0.37^a∗∗∗	6.07±0.49^b∗∗∗
GPx	7.44 ± 0.99	7.66 ± 0.84	4.37±0.52^a∗∗∗	6.60±0.59^b∗∗∗
GR	0.42 ± 0.04	0.43 ± 0.03	0.19±0.02^a∗∗∗	0.38±0.03^b∗∗∗
G6PD	571.2 ± 28.6	586.1 ± 23.9	292.9±20.4^a∗∗∗	496.9±19.2^b∗∗∗

Values are expresses as mean ± S.D. for six mice in each group. SOD: amount of enzyme required to exhibit 50% dismutation of superoxide radical/mg protein; catalase: nmoles of H₂O₂ consumed/min/mg protein; GPX: mmoles of GSH oxidized/min/mg protein; GR: nmoles of NADPH consumed/min/mg protein; G6PD: nmoles of NADPH liberated/min/mg protein. Values are statistically significant at ^∗∗𝑃<0.01 and ^∗∗∗𝑃<0.001. ^aob/ob mice were compared with lean control mice; ^bob/ob mice were compared with ob/ob-resveratrol treated mice. NS represents nonsignificant.