Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft

Figure 3

Mechanical stretch increased Egr-1 expression in wild-type (WT) mice. (a) Egr-1 mRNA levels in endothelial cells (ECs) increased 3 h after grafting the vein in WT mice (𝑛=5). *𝑃<0.05 versus sham group. Time course of Egr-1 mRNA (b) and protein (c) expression in ECs from WT mice after mechanical stretch (60 cycles/min and 15% elongation) for 0 to 150 min (𝑛=5). GAPDH was used as an internal control. Data are expressed as mean ± SEM. *𝑃<0.05 versus 0 min.

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