The Influence of Long Term Hydrochlorothiazide Administration on the Relationship between Renin-Angiotensin-Aldosterone System Activity and Plasma Glucose in Patients with Hypertension

Table 3

Relationship between changes in RAAS and changes in plasma glucose after one year of HCTZ therapy.

RAAS activity		After one year of medication		𝜒^2	P
		GLU elevated patients	GLU nonelevated patients
PRA	Elevated group	13	32
	Nonelevated group	17	58	0.696	0.404
ACE	Elevated group	19	43
	Nonelevated group	12	45	1.226	0.268
Ang II	Elevated group	17	25
	Nonelevated group	13	67	8.023	0.005
ALD	Elevated group	16	34
	Nonelevated group	14	55	2.109	0.146

Data in Table 3 demonstrates that there was a statistically significantly higher (𝑃<0.05) proportion of patients with a higher GLU in the Ang II elevated group compared with the Ang II nonelevated group.