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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 454328, 11 pages
http://dx.doi.org/10.1155/2013/454328
Research Article

Gamma-Tocotrienol Modulated Gene Expression in Senescent Human Diploid Fibroblasts as Revealed by Microarray Analysis

1Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
2Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

Received 14 December 2012; Revised 13 February 2013; Accepted 13 February 2013

Academic Editor: Narasimham L. Parinandi

Copyright © 2013 Suzana Makpol et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Nasimudeen R. Jabir, Chelapram K. Firoz, Saleh S. Baeesa, Ghulam Md Ashraf, Suhail Akhtar, Warda Kamal, Mohammad A. Kamal, and Shams Tabrez, “Synopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases,” CNS Neuroscience & Therapeutics, 2014. View at Publisher · View at Google Scholar
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  • Jaafar, Wan Ngah, Suzana Makpol, Durani, Tan, Tajul Arifin, and Mohd Yusof, “Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts,” Clinica Terapeutica, vol. 166, no. 6, pp. 365–373, 2015. View at Publisher · View at Google Scholar
  • Azalina Zainuddin, Kien-Hui Chua, Jen-Kit Tan, Faizul Jaafar, and Suzana Makpol, “γ-Tocotrienol prevents cell cycle arrest in aged human fibroblast cells through p16INK4a pathway,” Journal of Physiology and Biochemistry, vol. 73, no. 1, pp. 59–65, 2016. View at Publisher · View at Google Scholar
  • Jen-Kit Tan, Faizul Jaafar, and Suzana Makpol, “Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol,” BMC Complementary and Alternative Medicine, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar
  • Hye-Kyeong Kim, and Sung Nim Han, “Vitamin E: Regulatory role on gene and protein expression and metabolomics profiles,” IUBMB Life, 2019. View at Publisher · View at Google Scholar