Gamma-Tocotrienol Modulated Gene Expression in Senescent Human Diploid Fibroblasts as Revealed by Microarray Analysis

Table 3

Selected significant biological processes that were modulated in senescent HDFs after γ-tocotrienol treatment for 24 h.

Biological process	Gene Set Enrichment Analysis (GSEA)
	Normalized Enrichment Score	Gene symbol	Description
Negative regulation of tumor necrosis factor production	1.54164
		IRAK3	Interleukin-1 receptor-associated kinase 3
		Sels	selenoprotein S
Negative regulation of interleukin-6 production	1.65684
		IRAK3	Interleukin-1 receptor-associated kinase 3
		Sels	selenoprotein S
Negative regulation of caspase activity	1.40798
		HSPA5	Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)
		HERPUD1	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Response to stress	1.61171
		HSPA5	Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)
		HERPUD1	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
		DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9
		SERP1	Stress-associated endoplasmic reticulum protein 1
Protein transport	1.68316
		C18orf55	Chromosome 18 open reading frame 55
		ARF4	ADP-ribosylation factor 4
		RINT1	RAD50 interactor 1
		SERP1	Stress-associated endoplasmic reticulum protein 1
		NXT1	NTF2-like export factor 1
		CADPS2	Ca^2+—dependent activator protein for secretion 2
		COG6	Component of oligomeric golgi complex 6
Cell redox homeostasis	1.56752
		GLRX5	Glutaredoxin 5 homolog
		Sels	Selenoprotein S