Table 3
Selected significant biological processes that were modulated in senescent HDFs after γ-tocotrienol treatment for 24 h.
| | Biological process |
Gene Set Enrichment Analysis (GSEA) | | Normalized Enrichment Score | Gene symbol | Description |
| | Negative regulation of tumor necrosis factor production | 1.54164 | | | | | | IRAK3 | Interleukin-1 receptor-associated kinase 3 | | | | Sels | selenoprotein S |
| | Negative regulation of interleukin-6 production | 1.65684 | | | | | | IRAK3 | Interleukin-1 receptor-associated kinase 3 | | | | Sels | selenoprotein S |
| | Negative regulation of caspase activity | 1.40798 | | | | | | HSPA5 | Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) | | | | HERPUD1 | Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 |
| | Response to stress | 1.61171 | | | | | | HSPA5 | Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) | | | | HERPUD1 | Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | | | | DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | | | | SERP1 | Stress-associated endoplasmic reticulum protein 1 |
| | Protein transport | 1.68316 | | | | | | C18orf55 | Chromosome 18 open reading frame 55 | | | | ARF4 | ADP-ribosylation factor 4 | | | | RINT1 | RAD50 interactor 1 | | | | SERP1 | Stress-associated endoplasmic reticulum protein 1 | | | | NXT1 | NTF2-like export factor 1 | | | | CADPS2 | Ca2+—dependent activator protein for secretion 2 | | | | COG6 | Component of oligomeric golgi complex 6 |
| | Cell redox homeostasis | 1.56752 | | | | | | GLRX5 | Glutaredoxin 5 homolog | | | | Sels | Selenoprotein S |
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