Oxidative Medicine and Cellular Longevity / 2013 / Article / Tab 3

Research Article

Gamma-Tocotrienol Modulated Gene Expression in Senescent Human Diploid Fibroblasts as Revealed by Microarray Analysis

Table 3

Selected significant biological processes that were modulated in senescent HDFs after γ-tocotrienol treatment for 24 h.

Biological process Gene Set Enrichment Analysis (GSEA)
Normalized Enrichment ScoreGene symbolDescription

Negative regulation of tumor necrosis factor production1.54164
IRAK3Interleukin-1 receptor-associated kinase 3
Selsselenoprotein S

Negative regulation of interleukin-6 production1.65684
IRAK3Interleukin-1 receptor-associated kinase 3
Selsselenoprotein S

Negative regulation of caspase activity1.40798
HSPA5Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)
HERPUD1Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

Response to stress1.61171
HSPA5Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)
HERPUD1Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 9
SERP1Stress-associated endoplasmic reticulum protein 1

Protein transport1.68316
C18orf55Chromosome 18 open reading frame 55
ARF4ADP-ribosylation factor 4
RINT1RAD50 interactor 1
SERP1Stress-associated endoplasmic reticulum protein 1
NXT1NTF2-like export factor 1
CADPS2Ca2+—dependent activator protein for secretion 2
COG6Component of oligomeric golgi complex 6

Cell redox homeostasis1.56752
GLRX5Glutaredoxin 5 homolog
SelsSelenoprotein S