Antigenotoxic and Apoptotic Activity of Green Tea Polyphenol Extracts on Hexavalent Chromium-Induced DNA Damage in Peripheral Blood of CD-1 Mice: Analysis with Differential Acridine Orange/Ethidium Bromide Staining

Table 1

Averages of the induction MN-PCEs in peripheral blood of mice treated with polyphenol extracts of green tea and CrO₃.

Treatment	Dose (mg/kg)	𝑛	Time analysis (hours)	MN-PCEs 2,000 cells (mean ± S.D.)	ANOVA
Control	0	5	0	0.6±0.9
			24	0.8±0.8
			48	1.2±0.8
			72	1.6±1.5
Polyphenol extracts of green tea	30	5	0	1.0±1.2
			24	1.8±1.9
			48	1.2±1.3
			72	1.4±0.5
CrO3	20	5	0	0.2±0.5
			24	3.0±1.6
			48	13.2±3.8	a, b, c, d
			72	3.4±1.1
Polyphenol extracts of green tea–CrO3	30–20	5	0	1.2±1.3
			24	0.6±0.5
			48	5.2±1.8	a, b, e
			72	1.2±1.1

^a𝑃< versuscontrol 48 h; ^b𝑃< versus polyphenol extracts of green tea 48 h; ^c𝑃< versus CrO₃ 0 h; ^d𝑃< versus polyphenol extracts of green tea–CrO₃ 48 h; ^e𝑃< versus polyphenol extracts of green tea–CrO₃ 0 h.