The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells

Table 1

Human cancer cell targets of the proapoptotic effects of prominent traditional and modified NSAIDs.

NSAID type	Target cell type [references]
Traditional NSAIDs
Aspirin	Colon cancer cells [34–36], leukaemia cells [37, 38], cervical cancer cells [39, 40], gastric cancer cells [41–44], hepatocellular carcinoma cells [45, 46], endometrial cancer cells [29], neuroblastoma cells [47]
Indomethacin	Colon cancer cells [7, 35], Gastric cancer cells [44], Endometrial cancer cells [29]
Sulindac	Colon cancer cells [6, 7, 48, 49], prostate cancer cells [48], hepatocellular carcinoma cells [8], lung cancer cells [50]
Ibuprofen	Colon cancer cells [51]
Diclofenac	Neuroblastoma cells [15], melanoma cells [16]
Tolfenamic Acid	Prostate cancer cells [52]
Modified NSAIDs
NO-Aspirin	Pancreatic cancer cells [53], colon cancer cells [17, 54–58]
NO-sulindac	Colon cancer cells [17], melanoma cells [59]
NO-ibuprofen	Colon cancer cells [17]
NOSH-aspirin	Colon cancer cells [24]
Phosphoaspirin	Colon [19, 21, 56], pancreatic [21], and breast [21] cancer cells
Phosphosulindac	Colon, pancreatic, and breast cancer cells [21]
HS-aspirin	Colon cancer cells [22], breast cancer cells [60]
HS-ibuprofen	Colon cancer cells [22]
HS-naproxen	Colon cancer cells [22]
HS-sulindac	Colon cancer cells [22]