The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging

Figure 1

The CD163 pathway for uptake of Hb-Hp complexes and the CD91 pathway for uptake of hemopexin- (Hx-) heme complexes. The endocytosis of the ligand leads to degradation in lysosomes while the receptor recycles from the endosomes back to the plasma membrane.