Effects of Caloric Restriction on Cardiac Oxidative Stress and Mitochondrial Bioenergetics: Potential Role of Cardiac Sirtuins

<table>Possible mechanisms by which CR attenuates oxidative stress. CR: caloric restriction, PGC-1<i>α</i>: peroxisome proliferator-activated receptor <i>γ</i> coactivator 1<i>α</i>, NRF1: nuclear respiratory factor 1, FoxO1: forkhead transcriptional factor 1, NOS: nitric oxide synthase.</table>

Oxidative Medicine and Cellular Longevity

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Figure 2: Effects of Caloric Restriction on Cardiac Oxidative Stress and Mitochondrial Bioenergetics: Potential Role of Cardiac Sirtuins 