Roles Nrf2 Plays in Myeloid Cells and Related Disorders

Figure 1

Keap1-Nrf2 stress response system. Stress-sensing system of Keap1 and Nrf2. Environmental stresses, including ROS and electrophiles, inactivate Keap1 and stall the ubiquitination and degradation of Nrf2. Nrf2 accumulates in the nucleus and forms a heterodimer with the sMaf protein. The binding of the Nrf2-sMaf heterodimer to the EpRE/ARE motif leads to the transactivation of Nrf2 target genes, which include a battery of antioxidant and detoxifying genes required for cellular protection.