Roles Nrf2 Plays in Myeloid Cells and Related Disorders

Figure 4

Physiological roles of Nrf2 in myeloid cells. The roles of Nrf2 in myeloid cells have been clarified in disease models. In tumor development models, Nrf2 suppresses ROS in MDSCs, in which ROS is required for the suppression of T cells. Thus, Nrf2 supports antitumor immunity and reduces tumor metastasis. In an ApoE-deficient atherosclerotic mouse model, Nrf2 upregulates the scavenger receptor CD36 and promotes atherogenesis.