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Oxidative Medicine and Cellular Longevity
Volume 2013 (2013), Article ID 575482, 15 pages
Review Article

A Review of Pterostilbene Antioxidant Activity and Disease Modification

1Mailman School of Public Health, Columbia University, Allan Rosenfield Building, 722 West 168th Street, New York, NY 10032, USA
2Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA

Received 13 February 2013; Accepted 18 March 2013

Academic Editor: Nilanjana Maulik

Copyright © 2013 Denise McCormack and David McFadden. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a natural dietary compound and the primary antioxidant component of blueberries. It has increased bioavailability in comparison to other stilbene compounds, which may enhance its dietary benefit and possibly contribute to a valuable clinical effect. Multiple studies have demonstrated the antioxidant activity of pterostilbene in both in vitro and in vivo models illustrating both preventative and therapeutic benefits. The antioxidant activity of pterostilbene has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes. In this review, we explore the antioxidant properties of pterostilbene and its relationship to common disease pathways and give a summary of the clinical potential of pterostilbene in the prevention and treatment of various medical conditions.