601587.fig.003
Figure 3: Hypothetical schematic representation of the PINK1 regulatory pathway and Parkin mediated-mitophagy. Under healthy and steady state, PINK1 is degraded within the mitochondria. This may be inhibited by mitochondrial damage, resulting in PINK1 and Parkin accumulation in the outer membrane of mitochondria. Parkin is presumed to ubiquitinate unidentified substrate (black circle), resulting in the induction of mitophagy. Note that some critical pathways have been omitted for clarity. OMM: outer mitochondrial membrane; IMM: inner mitochondrial membrane.