Neurotoxic Effects of trans-Glutaconic Acid in Rats

Figure 2

In vitro effect of trans-glutaconic acid (tGA) on oxidative damage parameters (a) carbonyl and sulfhydryl content and (b) TBA-RS levels and spontaneous chemiluminescence in cerebral cortex of 30-day-old rats. The experiments were performed in triplicate and are plotted as mean ± S.E.M. (𝑛=5-6). Carbonyl and sulfhydryl content and TBA levels are expressed as nmol·mg protein⁻¹; chemiluminescence values are expressed as cpm·mg protein⁻¹. ^∗𝑃<0.05; ^∗∗𝑃<0.01 and ^∗∗∗𝑃<0.001 compared to control group (Duncan multiple range test).

(a)

(b)