ALS and Oxidative Stress: The Neurovascular Scenario

Figure 3

Hypoxia induced mobilisation of astrocytes. Astrogliosis is the result of aggressive increase of astrocytes number in the vicinity of damaged neuron cell. Synapse formation is hampered when there is neuronal damage thus leading to breakdown of Na⁺K⁺ homeostasis. This K⁺ concentration is detected by the astrocytes.