Enhanced Prostacyclin Synthesis by Adenoviral Gene Transfer Reduced Glial Activation and Ameliorated Dopaminergic Dysfunction in Hemiparkinsonian Rats
Figure 5
Infective tropism of adenovirus encoding GFP (AdGFP), which was injected into the substantia nigra (SN) 3 days ago. Representative micrographs of double labeling staining of coronal sections in the injection site. (a)(d) Photos (magnification 200) of each double staining; green color: GFP immunoreactivity (IR); red color: TH-IR (panel a), nestin-IR (panel b), GSLI-IB4-IR (panel c) and GFAP (panels d). Arrows or arrow heads in the figures indicate double-IR. AdGFP could transduce dopaminergic (TH-IR) neurons and GSLI-IB4-IR microglia in the SN.
