Oxidant Status and Lipid Composition of Erythrocyte Membranes in Patients with Type 2 Diabetes, Chronic Liver Damage, and a Combination of Both Pathologies

Table 4

Conjugated dienes, carbonyls and TBARS generation in red blood cell membranes obtained from control subjects and in patients with type 2 DM and cirrhosis.

Parameter	Healthy (𝑛=60)	Diabetes (𝑛=60)	Cirrhosis (𝑛=70)	Diab + Cirrhos (𝑛=25)
Conjugated dienes (Δ233/mg)	0.19±0.07	0.11±0.06	0.26±0.12^∗	0.12±0.03^∗∗∗
Carbonyl groups (nmoles/mg)	2.73±0.90	1.83±0.85^∗	1.85±0.89^∗	1.86±0.38^∗
TBARS generation by RBC membranes	10.9±0.9	10.5±1.4	4.8±1.0^∗	20.7±1.8^∗,∗∗∗

Results are expressed as mean ± SD of determinations done in RBC membranes from controls (𝑛=60), patients with type 2 DM (𝑛=60), cirrhotic patients (𝑛=70), and diabetic patients with cirrhosis (𝑛=25). Statistical significance: *𝑃<0.01, versus control; **𝑃<0.01, versus DM or versus cirrhosis; ***𝑃<0.01, versus both the diabetes and cirrhosis groups, separately.