The Effect of Preoperative Melatonin on Nuclear Erythroid 2-Related Factor 2 Activation in Patients Undergoing Coronary Artery Bypass Grafting Surgery

Table 3

Perioperative and postoperative data of the patients*.

Variable/sampling time	Group I (Melatonin)	Group II (placebo)	𝑃^†	𝑃^‡
Cross-clamp time, min	49.7 ± 18.4	42.7 ± 5.0	NS	NA
CPB time, min	65.0 ± 10.1	70.6 ± 8.7	NS	NA
Po2
𝑇3	349 ± 66.6	323 ± 44.4	NS	<0.001 (Group I)
𝑇4	63.1 ± 14.1	42.4 ± 4.8	NS	<0.001 (Group II)
O2 sat
𝑇3	75.4 ± 11.2	79.7 ± 9.8	NS	NS
𝑇4	71.4 ± 22.7	62.8 ± 15.2	NS	<0.05 (Group II)
Pco2
𝑇3	39.2 ± 6.1	42.0 ± 220	NS	<0.05 (Group I)
𝑇4	45.8 ± 8	45.7 ± 4.3	NS	NS
𝑇3	28.8 ± 5.6	27.3 ± 5.6	NS	NS
𝑇4	27.2 ± 2	27.3 ± 2.1	NS	NS

*Data are presented as the mean ± SD. Sampling times were preoperatively before the aortic cross-clamp was placed (𝑇3) and at 45 min (𝑇4) postoperatively. NS: not statistically significant; CPB: cardiopulmonary bypass; and NA: not applicable.
^†𝑃 values for the difference between groups I and II at the same time point.
^‡𝑃 values determined by paired 𝑡-test for differences at consecutive time points between groups.