Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases: Possible Impact of Environmental Exposures
Figure 2
Unsupervised hierarchical clustering analysis of 61 selected genes involved in brain copper/iron homeostasis, comparing gene expression profiles of AD and unaffected age-matched controls. Unsupervised hierarchical clustering analysis (complete-linkage and Manhattan distance similarity measurement) is based on similarities in gene expression. The 21 SAM-identified genes are color coded (right side of figure) based on the group they belong to: red color code represents 11 overexpressed genes, while green color code represents 10 underexpressed genes. The horizontal red color bar indicates AD-affected samples (), whereas the green bar indicates normal elderly controls ().
