NRF2-ome: An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2

Figure 4

Combined snapshots of the NRF2-ome web resource. (a)–(d) The protein datasheet page of KEAP1. (a) The header contains the full name, gene name, UniProt ID, and Ensembl ENSP ID of KEAP1. (b) The interaction list of KEAP1 shows the interactions by types and also the ‘‘Pathway connections’’ section, which shows one- or two-step-long connections to signaling pathway member proteins. Detailed information on the interactions can be accessed by clicking on the triangles appearing below each interaction. (c) The slide-down box contains sources, references, and confidence scores of the interactions. (d) The protein datasheet page also contains an interactive visualization of the network of KEAP1. (e) NRF2 has a special datasheet page at the website, which makes interaction browsing easier for the users. On the bottom of NRF2 datasheet, page users can choose the interaction types to be shown as well as the regulatory loops involving NRF2. Here, all arrows symbolizing interactions are clickables, to get the same information about the interaction as on the protein datasheet. We show the details of the regulatory loop involving MAFG and mir-144 as an example.