Resveratrol Suppresses PAI-1 Gene Expression in a Human In Vitro Model of Inflamed Adipose Tissue
Figure 2
PAI-1 gene expression is upregulated in an in vitro model of inflamed human adipose tissue. (a) SGBS adipocytes were incubated with increasing doses of macrophage-conditioned media (MacCM) or vehicle for 48 h. PAI-1 mRNA levels were analyzed by qPCR and results were normalized to HPRT. *significant difference control versus MacCM. (b) Primary human ex vivo differentiated adipocytes isolated from 3 patients were treated with 10% macrophage-conditioned media (MacCM) or vehicle for 48 h. PAI-1 mRNA levels were analyzed with qPCR and normalized to HPRT. *significant difference control versus MacCM.
