Oxidative Medicine and Cellular Longevity / 2013 / Article / Fig 1

Review Article

Diversity of Mitochondrial Pathology in a Mouse Model of Axonal Degeneration in Synucleinopathies

Figure 1

Schematics of the pathogenic mechanism of familial and sporadic α-synucleinopathies. Loss of function of the PINK1-Parkin pathway may be causative in the mitochondrial dysfunctions of some familial PD, while gain of functions of α-synuclein and LRRK2 may play a central role in the pathogenesis of sporadic PD.

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